Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy

Nematollahi-Mahani, S. N. and Azizollahi, G. H. and Baneshi, M. R. and Safari, Z. and Azizollahi, S. Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy. Andrologia.

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Abstract

Varicocele is among the most common problems which may lead to male infertility. Spermatogenesis is impaired as a consequence of this vascular defect, through mechanisms that are not well described. This study aimed to evaluate serum hormonal level (inhibin B, FSH and testosterone) and seminal plasma antioxidant defence levels after folic acid and zinc sulphate administration in varicocelectomised patients. Participants were randomly allocated to four experimental groups. Our randomisation schedule was as follows: zinc sulphate/ folic acid, folic acid, zinc sulphate and placebo. The patients underwent varicocelectomy, before which a blood and semen sample were obtained and also three and six months after varicocelectomy for evaluation of blood hormonal level (FSH, testosterone, inhibin B) and seminal oxidative stress status (nitric oxide, superoxide dismutase, total antioxidant capacity). Patients in different groups took orally one capsule per day after dinner following varicocelectomy for 6 months. A significant rise in peripheral blood inhibin B and seminal plasma activity was detected in the zinc sulphate/folic acid group after 6 months. The present clinical trial indicates a change in the hormonal status of varicocelectomised patients following long-term administration of zinc sulphate and folic acid.

Item Type: Article
Subjects: A General Works > AI Indexes (General)
Depositing User: Unnamed user with email info@noyanco.ir
Date Deposited: 05 Nov 2018 09:24
Last Modified: 05 Nov 2018 09:24
URI: http://eprints.kmu.ac.ir/id/eprint/29364

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