Opium as a Risk Factor for Bladder Cancer: A Population-based Case-control Study in Iran

Akbari, Morteza and Naghibzadeh-Tahami, A and Khanjani, Narges and Baneshi, Mohammad Reza and Kamali, E and Hesampour, M and Nazemzadegan, B and Haghdoost, Ali-Akbar (2015) Opium as a Risk Factor for Bladder Cancer: A Population-based Case-control Study in Iran. Arch Iran Med, 18 (9). pp. 567-71.

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Abstract

Bladder cancer (BC) is the most common genitourinary system malignancy in humans. Consumption of opium and its derivatives, maybe a risk factor possibly in Iran. The aim of this study was to investigate the relationship between consumption of opium and its derivatives and the incidence of BC. METHODS: In an individually matched case-control study in Shiraz (located in the south of Iran), 198 patients with BC and 396 healthy individuals (matched in age, sex and residence (urban/rural)) were investigated. Data about consumption of opium and its derivatives, tobacco, alcohol and diet were collected using a structured valid and reliable questionnaire. Crude and adjusted odds ratios (ORs) were computed using conditional logistic regression models. RESULTS: Opium consumption was associated with an increased risk of BC with an adjusted OR = 3.9 (95% CI: 1.2 - 12.0). Moreover, a considerable dose-response relationship was observed between the opium consumption and its derivatives and the incidence of BC; comparing to no users, the odds ratios of low and high consumptions were 3.3 (95% CI: 0.5 - 23.1) and 4.9 (95% CI: 1.1 - 21.9) respectively. CONCLUSION: Opium consumption can be a potential strong risk factor for BC in Iran.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Depositing User: azam bazrafshan bazrafshan
Date Deposited: 22 Dec 2015 04:52
Last Modified: 22 Dec 2015 04:52
URI: http://eprints.kmu.ac.ir/id/eprint/22831

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