Hydroalcoholic extract of Carum carvi L. in oral mucositis: A clinical trial in male golden hamsters

Tanideh, N and Afra, SM and Mardani, M and Andisheh Tadbir, A and Modarresi, F and Koohi-Hosseinabadi, O and Iraji, A and Sepehrimanesh, M (2015) Hydroalcoholic extract of Carum carvi L. in oral mucositis: A clinical trial in male golden hamsters. Oral Dis.

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OBJECTIVES: Several studies have attempted to prevent or improve oral mucositis (OM) but have not produced a qualified treatment yet. This study evaluates the effects of Carum carvi L. (caraway) hydroalcoholic extract (CHE) as one of the traditional medicinal plants in 5-flurouracile (5-FU) induced OM in golden hamsters. MATERIALS AND METHODS: OM was induced in 54 male golden hamsters by 5-FU and cheek pouch scratching. Starting from day 12, 500 and 1000 mg/kg/day dietary CHE were administered. Pouch histopathology score, malondialdehyde and reduced glutathione contents, and activity of myeloperoxidase plus microbial cultures of cheek pouch, antimicrobial properties of CHE, and essential oil constituents were evaluated. RESULTS: Lower histopathology score (0, 1, and 2) and malondialdehyde level, higher reduced glutathione level and activities of myeloperoxidase were detected in 1000 and 500 mg/kg/day dietary CHE and control groups, respectively (P<0.001). The CHE was more potent against Staphylococcus epidermidis and Streptococcus intermedius. γ-terpinene (37.2%) was identified as the main constituent of essential oil. CONCLUSION: The use of CHE in dietary form may be associated with reduced intensity of OM. This may be due to appropriate antibacterial activity and terpinene contents. This article is protected by copyright. All rights reserved.

Item Type: Article
Uncontrolled Keywords: 5-flurouracil; Carum carvi L; Oral mucositis; histopathology score; oxidative stress
Subjects: R Medicine > RK Dentistry
Depositing User: azam bazrafshan bazrafshan
Date Deposited: 20 Dec 2015 09:15
Last Modified: 20 Dec 2015 09:15
URI: http://eprints.kmu.ac.ir/id/eprint/22693

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