Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma

Zeinali, M and Adelinik, A and Papian, S and Khorramdelazad, H and Abedinzadeh, M (2015) Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma. Hum Immunol, 76 (10). pp. 770-4.

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Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing evidence that galectins are implicated in essential biological processes such as cellular communication, inflammation, differentiation and apoptosis. Galectin-3 is one of the best-known galectins, which is found in vertebrates. Galectin-3 has been shown to be expressed in some cell lines and plays important roles in several physiological and pathological processes, including cell adhesion, cell activation and chemoattraction, cell cycle, apoptosis, cell growth, and differentiation. Moreover, this galectin is of interest due to its involvement in regulation of cancer. Changes in galectin-3 expression are commonly seen in cancerous and pre-cancerous conditions and galectin-3 may be involved in the regulation of cancer cell activities that contribute to tumourigenesis, cancer progression and metastasis. Finally, galectin-3 seems to be involved in cell events in tumor microenvironment, and therefore it could be considered as a target in transitional cell carcinoma therapies. This review aims to describe recent progress in understanding the role of galectin-3 in cancer biology, with emphasis on bladder tumor progression and metastasis.

Item Type: Article
Uncontrolled Keywords: Bladder cancer; Galectin-3; TCC; Tumor
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Depositing User: azam bazrafshan bazrafshan
Date Deposited: 20 Dec 2015 08:54
Last Modified: 20 Dec 2015 08:54

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